BetaSys book, chapters, 6 May 2010
Systems biology of regulated exocytosis in pancreatic ß-cells

Editors: Bernhelm Booß-Bavnbek, Roskilde University, Denmark, booss@ruc.dk (chief editor),
Beate Klösgen, Odense University, Denmark, kloesgen@memphys.sdu.dk,
Jesper Larsen, Roskilde University, Denmark, Jesperla@ruc.dk,
Flemming Pociot, Hagedorn Laboratories, Denmark, fpoc@hagedorn.dk,
Erik Renström, Lund University, Sweden, Erik.Renstrom@med.lu.se

Instructions

·         (ZIP)                                            General Springer instructions for word files

·        (ZIP)                                             General Springer instructions for LaTeX files

·        (ZIP)                                             BetaSys instructions and templates for Word and LaTeX files

Draft chapters received

0. Front Matter, Book Structure (revised) and Back Cover (editors’ draft), revised April 28, 2010                                                   

·        (DOC)                                          Frontmatter-Backcover\Preface.doc

·        (DOC)                                          Frontmatter-Backcover\Book_Structure_revised.doc

·        (DOC)                                          Frontmatter-Backcover\Backcover.doc

·        (PDF)                                            TOC  (status: Thursday, 06 May 2010)

1. Systems biology of ß-cells, revisited, Flemming Pociot, Gentofte, 6085 words, 5 colour plates, revised April 9, 2010

·        (PDF)                                            1_Pociot\1_Pociot.pdf

·        (WORD)                                       1_Pociot\1_Pociot.doc  (index entries in blue)

·        (PDF)                                            1_Pociot\1_Pociot_fig.pdf

·        (PPT)                                            1_Pociot\1_Pociot_fig.ppt  (presentation file)

·        Box 1.1 (WORD)                          Boxes\BetaSys_Box1-1_Bertalanffy.doc

·        Box 1.1 (PDF)                              Boxes\BetaSys_Box1-1_Bertalanffy.pdf

·        Box 1.2 (WORD)                          Boxes\BetaSys_Box1-2_DiabetesHostory_rev.doc

 

2. Established facts and open questions of the focused systems analysis of regulated exocytosis in β-cells, Erik Renström, Lund, 11502 words, 3colour and 4 b/w figures, revised April 19, 2010

·        (PDF)                                            2_Renstrom\Renstrom_Springer_new.pdf

·        (WORD)                                       2_Renstrom\Renstrom_Springer_new.doc

·        (WORD)                                       2_Renstrom\Renstrom_Springer_indexed.doc (marked index words)

·        (PDF)                                            2_Renstrom\Springerbook renstrom Figs.pdf

·        Box 2.1 (WORD)                          Boxes\BetaSys_Box2-1a_TypicalLengths.doc

·        Box 2.1 (PDF)                              Boxes\BetaSys_Box2-1a_TypicalLengths.pdf

·        Box 2.2 (WORD)                          Boxes\BetaSys_Box2-1b_Microscopy.doc

·        Box 2.2 (PDF)                               Boxes\BetaSys_Box2-1b_Microscopy.pdf

 

3. Withdrawn

 

4. Mitochondria and metabolic signals in β-cells, Pierre Maechler, Génève, 8011 words, 2 b/w figures, revised Feb. 1, 2010  

·        (PDF)                                            4_Maechler\Corrected-Chapter4-BetSys-100330pm.pdf

·         (WORD)                                      4_Maechler\Corrected-Chapter4-BetSys-100330pm.doc (doc index)

·        (TIF)                                             4_Maechler-Fig-4-1.TIF

·        (TIF)                                             4_Maechler-Fig-4-2.TIF

·        Box 4.1 (WORD)                          Boxes\BetaSys_Box4-1_Organelles.doc

 

5. Beta-cell ontogenesis and the insulin production apparatus, R. Scott Heller and Ole D. Madsen, Gentofte, 3346 words, 1 figure, revised April 16, April 23, 2010

·        (PDF)                                            5_Heller-Madsen\Heller-Madsen_final.pdf

·        (WORD)                                       5_Heller-Madsen\Heller-Madsen_final.doc

·        Index (WORD)                             5_Heller-Madsen\5_Index.doc (Index entries in alphabetical order)

·        Figure (PDF)                                 5_Heller-Madsen\Figure 1.pdf                                        

·        (TIF)

 

6. The Mathematical Microscope - Making the inaccessible accessible, Johnny T. Ottesen, Roskilde, 7729 words, 3 figures, revised Jan. 21, 2010

·        (PDF)                                            6_Ottesen\6_Ottesen_Final.pdf

·        (WORD)                                       6_Ottesen\6_Ottesen_Final.doc  (index entries in blue)

·        (PDF)                                            6_Ottesen\6_Ottesen_Final_Figures.pdf

·        (WORD)                                       6_Ottesen\6_Ottesen_Final_Figures.doc

·        Box 6.1 (WORD)                          Boxes\BetaSys_Box6-1_Harvey.doc

·        Box 6.1 (PDF)                              Boxes\BetaSys_Box6-1_Harvey.pdf

·        Box 6.2 (WORD)                          Boxes\BetaSys_Box6-2_ModelClassification.doc

·        Box 6.2 (PDF)                              Boxes\BetaSys_Box6-2_ModelClassification.pdf

 

 

 

7. Withdrawn

 

8. Magnetic resonance imaging of pancreatic β-cells, Patrick F. Antkowiak and Frederick H. Epstein, Charlottesville, and Ragha­ven­dra G. Mirmira, Indianapolis, 10016 words, 13 b/w, revised April 19, 2010

·        (WORD)                                       8_Antkowiak\8_Antkowiak_revised_BK_pfa1.doc (doc index)

·         (PDF)                                           8_Antkowiak\8_Antkowiak_figures.pdf

·         (WORD)                                      8_Antkowiak\8_Antkowiak_figures.doc

·        Box 8.1 (WORD)                          Boxes\BetaSys_Box8.1_MagneticResonance.doc

 

9. Mapping the β-cell in 3D at the nanoscale using  novel cellular electron tomography and computational approaches, Andrew B. Noske and Brad J. Marsh, Queensland, Australia, 8 figures (5 colour plates and 3 b/w), revised May 5, 2010

·        (WORD, Indexed)                         9_Noske-Marsh\08_NOSKE&Marsh_Indexed.doc (Index list in the end)

·        (ZIP, high resolution)                      9_Noske-Marsh\Figures1-8_NOSKE&MARSH.zip

·        Box 9.1 (WORD)                          Boxes\BetaSys_Box9.1_Tomography.doc

 

10. In-vivo applications of inorganic nanoparticles, Maria T. Fernandez, Fernandez Arguelles*, Joseph Bear, Gaelle Charron, Salam Massadeh, Paul McNaughter, Thomas Nann, Norwich, 15,435 words, 3 figures (2 colour, 1 optional colour or b/w), revised April 30, 2010

 

11. Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: Basic concepts, Angela M. Otto, München, 6625 words, 5 colour plates, 1 b/w, revised Mar. 11, 2010, April 5, 2010

·         (PDF)                                            11_Otto.pdf

·         (WORD)                                       11_Otto.doc (index entries marked in Italic)

·         (ZIP, high resolution)                      11_Otto.zip

·         Box 11.1 (WORD)                        Boxes\BetaSys_Box11.1_CellCultivation.doc

 

12. The role of the cytoskeleton in transport and release of insulin-containing granules by pancreatic β-cells, Roger S. Goody, Dortmund, and Hans Georg Mannherz, Bochum, 5249 words, no figures, revised April 28, 2010

·         (PDF)                                            E:\User\booss\htdocs\BetaSys\12_Mannherz\Goody&Mannherz_Springer_BK-1.pdf

·         (WORD)                                       E:\User\booss\htdocs\BetaSys\12_Mannherz\Goody&Mannherz_Springer_BK-1.doc

·         Index (WORD)                             E:\User\booss\htdocs\BetaSys\12_Mannherz\Goody&Mannherz_Springer_BK-1_index.doc (Index entries in blue)

·         Index list (WORD)                        E:\User\booss\htdocs\BetaSys\12_Mannherz\Index entries.doc (List of Index entries)

·         (PDF)                                            12_Mannherz\Fig 1.pdf

·         Box 12.1 (WORD)                        Boxes\BetaSys_Box12.1_Cytoskeleton.doc

 

13. Withdrawn

 

14. Bioimpedance Spectroscopy, Beate Klösgen, Odense, and Christine Rümenapp and Bernhard Gleich, München, revised Feb. 8, 2010

·         (PDF)                                            14_Gleich-Kloesgen\ImpSpectr_BetaSYS_050210.pdf

·         (WORD)                                       14_Gleich-Kloesgen\ImpSpectr_BetaSYS_050210.doc (doc index)

·         (ZIP, high resolution)                      14_Gleich-Kloesgen\Chapt14_PreprintFiles.zip

·         Box 14.1 (WORD)                        Boxes\BetaSys_Box14.1_BioimpedanceSpectroscopy.doc

 

15. DNA variations, impaired insulin secretion and type 2 diabetes, Valeriya Lyssenko and Leif Groop, Lund, 7398 words, 3 color plates, 3 b/w, revised Feb. 4, 2010, April 28, 2010

·         (PDF)                                            15_Groop-Lyssenko\Lyssenko Groop proof1 20100203corr-acc.pdf

·         (WORD)                                       15_Groop-Lyssenko\Lyssenko Groop proof1 20100203corr-acc.doc

·         Index (WORD)                             E:\User\booss\htdocs\BetaSys\15_Groop-Lyssenko\Lyssenko Indexed.doc (Index entries in blue)

·         (PPT)                                            15_Groop-Lyssenko\Figures 100115.ppt

·         Box 15.1 (WORD)                        Boxes\BetaSys_Box15-1_GeneticEpidemiology.doc

·         Box 15.1 (PDF)                            Boxes\BetaSys_Box15-1_GeneticEpidemiology.pdf

·         Box 15.2 (WORD)                        Boxes\BetaSys_Box15-2_GenotypingArrays.doc

·         Box 15.2 (PDF)                            Boxes\BetaSys_Box15-2_GenotypingArrays.pdf

·         Box 15.3 (WORD)                        Boxes\BetaSys_Box15.3_PatternRecognitionHMM_rev.doc

 

16. Genetically programmed defects in β-cell function, Aparna Pal and Anna Gloyn, Oxford, 9224 words, 2 colour plates (or 1 colour + 1b/w) revised Mar. 11, 2010, April 15, 2010, April 29, 2010

·        (PDF)                                            16_Gloyn\Pal & Gloyn_Final_indexed.pdf

·        (WORD)                                       16_Gloyn\Pal & Gloyn_Final_indexed.docm (Index entries marked in text, in blue)

·        Index (WORD)                             16_Gloyn\16_Index.doc (Index entries in alphabetical order)

·        (PDF)                                            16_Pal & Gloyn_Fig1.pdf

·        (PDF)                                            16_Gloyn\16_Pal & Gloyn_Fig2.pdf

·        Box 16.1 (WORD)                        Boxes\BetaSys_Box16-1_MonogenicFormsOfDiabetes_revised2.doc

·        Box 16.1 (PDF)                            Boxes\BetaSys_Box16-1_MonogenicFormsOfDiabetes_revised2.pdf

17. Proteomic analysis of the pancreatic islet ß-cell secretory granule: current understanding and future possibilities, Garth JS Cooper, University of Auckland, NZ, 11706 words, 10 figures, revised Jan. 25, 2010

·         (PDF)                                            17_Cooper\Beta cell Chapter MS R1 [v2].pdf

·         (WORD)                                       17_Cooper\Beta cell Chapter MS R1 [v2].doc

·         (ZIP, high resolution)                      Cooper Figures

·         (WORD, indexed)                         17_Cooper\Beta cell Chapter INDEXED.doc (doc indexed)

·         Box 17.1 (WORD)                        Boxes\BetaSys_Box17.1_ProteomicAnalysis_rev.doc

18. Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) – a role in the pathogenesis of type 2 diabetes, Gunilla Westermark, Linköping, revised April 19, 2010

·         (PDF)                                             18_Westermark\Westermark.pdf

·         (WORD)                                        18_Westermark\Westermark.doc

·         (WORD)                                       18_Westermark\Westermark_indexed.doc (doc indexed)

·         (WORD, high resolution)               18_Figure 1.docx

·         (PPT, high resolution)                      18_Figure 2.ppt

·         (WORD,legends)                           18_Legends.docx

·         Box 18.1 (WORD)                        Boxes\BetaSys_Box18-1_Amyloid.doc

 

19. Withdrawn

 

20. Present state of islet transplantation for type-1 diabetes patients, Torbjörn Lundgren, Stockholm, and Olle Korsgren, Uppsala, 7019 words, 3 figures on one plate (1 in colour, but readable in b/w) , revised Feb. 3, 2010

·         (PDF)                                            20_Korsgren-Lundgren\Present state of islet transplantation for type-1 diabetes patients nr3.pdf

·         (WORD)                                       20_Korsgren-Lundgren\Present state of islet transplantation for type-1 diabetes patients nr3.doc

·         (WORD)                                       20_Korsgren-Lundgren\Present state… _Indexed.doc (index entries marked with bold & red)

·         (PDF)                                            20_Korsgren-Lundgren\Figure 1.pdf

·         (PPT)                                            20_Korsgren-Lundgren\Figure 1.ppt

·         Box 20.1 (WORD)                        Boxes\BetaSys_Box20-1_TransplantationHistory.doc

·         Box 20.1 (PDF)                            Boxes\BetaSys_Box20-1_TransplantationHistory.pdf

 

21. Predictive protein networks and identification of drugable targets in the ß-cell, Joachim Størling and Regine Bergholdt, Gentofte, 3756 words, 1 colour plate, 1 b/w figure, revised Jan. 13, 2010

·         (PDF)                                            21_Storling-Bergholdt\21_Storling-Bergholdt.pdf

·         (WORD)                                       21_Storling-Bergholdt\21_Storling-Bergholdt.doc (index entries in green)

·         (PDF)                                            21_Bergholdt_fig.pdf

·         (PPT)                                            21_Bergholdt Figures (presentation file)

·         Box 21.1 (WORD)                        Boxes\BetaSys_Box21-1_ClinicalTrials.doc

·         Box 21.1 (PDF)                            Boxes\BetaSys_Box21-1_ClinicalTrials.pdf

·         Box 21.2 (WORD)                        Boxes\BetaSys_Box21-2_InsulinHistory.doc

·         Box 21.2 (PDF)                            Boxes\BetaSys_Box21-2_InsulinHistory.pdf

·         Box 21.3 (WORD)                        Boxes\BetaSys_Box21-3_DrugDevelopment.doc

·         Box 21.3 (PDF)                            Boxes\BetaSys_Box21-3_DrugDevelopment.pdf

 

22. Withdrawn

 

23. Nanotoxicity, Gary Hutchison and Eva Malone, Edinburgh, revised Mar. 22, 2010, April 28, 2010

·         (PDF)                                            E:\User\booss\htdocs\BetaSys\23_Hutchison-Malone\Malone_Springer_BK (5).pdf

·         (WORD)                                       E:\User\booss\htdocs\BetaSys\23_Hutchison-Malone\Malone_Springer_BK (5).docx (Index entries in blue)

·         Index list                                        E:\User\booss\htdocs\BetaSys\23_Hutchison-Malone\Index entries.docx (List of Index entries)

·         (JPG)                      23_Hatchison-Malone\Figure_1.jpg

·         Box 23.1 (WORD)                        Boxes\BetaSys_Box23.1_ClassicalToxicityStudies.doc

 

24. Withdrawn

25. From silicon cell to silicon human, Hans V. Westerhoff, Malkhey Verma, Frank J. Bruggeman, Alexey Kolodkin, Maciej Swat, Neil Hayes,  Maria Nardelli, and Jacky L. Snoep, Amsterdam, and Manchester, 8597 words, 8 figures (mostly colour, but readable in b), revised March. 11, 2010

·         (PDF)                                            25_Westerhoff\From silicon cell to silicon humacomb963ACCx.pdf

·         (WORD)                                       25_Westerhoff\From silicon cell to silicon humacomb963ACC.doc

·         (WORD_X)                                  25_Westerhoff\From silicon cell to silicon humacomb963ACC.docx (docx indexed)

·         Box 25.1 (WORD)                        Boxes\BetaSys_Box25-1a_Complexity.doc

·         Box 25.1 (PDF)                            Boxes\BetaSys_Box25-1a_Complexity.pdf

 

26. Probing cellular dynamics with mesoscopic simulations, Julian Shillcock, Odense, 6792 words, 1 colour plate, 1 b/w figure, revised April 18, 2010

·         (PDF)                                            26_Shillcock

·         (WORD)                                       26_Shillcock (word file)

·         Index Entries (WORD)                  26_Shillcock\26_Index.doc (Index entries in alphabetic order)

·          (BMP)                                          26_Shillcock-Fig26-1.bmp

·         (JPG)                                            26_Shillcock-Fig26-2.jpg

·         Box 26.1 (WORD)                        Boxes\BetaSys_Box26-1_MonteCarlo.doc

 

27. Withdrawn

 

28. What drives calcium oscillations in beta-cells? New tasks for cyclic analysis, Leonid E. Fridlyand and Louis H. Philipson, Chicago, 4937 words, 4 b/w figures, revised April 29, 2010

·         (PDF)                                            28_Fridlyand\28_Fridlyand and Philipson Final.pdf

·         (WORD)                                       28_Fridlyand\28_Fridlyand and Philipson Final.doc

·         Index (WORD)                             28_Fridlyand\28_Fridlyand and Philipson Index.doc (Index entries in yellow)

·         (PDF)                                            28_Fridlyand & Philipson -Fig-28-1-1.pdf

·         (PDF)                                            28_Fridlyand & Philipson -Fig-28-2.pdf

·         (PDF)                                            28_Fridlyand & Philipson -Fig-28-3.pdf

·         (PDF)                                            28_Fridlyand & Philipson -Fig-28-4.pdf

·         Box 28.1 (WORD)                        Boxes\BetaSys_Box28.1_FourierAnalysis.doc                                     

 

29. Whole-body and cellular models of glucose-stimulated insulin secretion, Gianna Maria Toffolo, Morten Gram Pedersen, and Claudio Cobelli, Padua, 5178 words, 4 b/w figures, accepted without revision, April 16, 2010

·         (PDF)                                            29-toffolo-pedersen-cobelli.pdf

·         (WORD)                                       29-toffolo-pedersen-cobelli.doc

·         Index (WORD)                             29_Toffolo\29-toffolo-pedersen-cobelli_Indexed.doc (Index entries in yellow)

·         (PDF)                                            29-toffolo-pedersen-cobelli-figure.pdf

·         (PPT)                                            29-toffolo-pedersen-cobelli-figure.ppt

·         Box 29.1 (WORD)                        Boxes\BetaSys_Box29.1_CompartmentModels.doc

 

30. Geometric and electromagnetic aspects of fusion pore making, Darya Apushkinskaya, Saarbrücken, Evgeny Apushkinsky, St. Petersburg, Bernhelm Booß-Bavnbek, Roskilde, and Martin Koch, København, 10949 words, 2 colour plates, 5 b/w figures revised April 7, 2010, and April 28, 2010

·         (PDF with compressed figures)      30_AABK\30_ApApBoKo_rev2.pdf

·         (ZIP, Source files)                          30_AABK\30_Figures_all-transportable\Booss_et_al.zip

·         Index entries (WORD)                   30_AABK\30_Index.doc (Index entries in alphabetic order)

·         Box 30.1 (WORD)                        Boxes\BetaSys_Box30-1_Maxwell.doc

·         Box 30.2 (WORD)                        Boxes\BetaSys_Box30-2_HighPower-Biophysics.doc

·         Box 30.3 (WORD)                        Boxes\BetaSys_Box30-3_Experiments.doc

·         Figures (High resolution, ZIP)         30_AABK\30_Three-Figures_HighResol.zip

                                     

 

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